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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
11.52
Human Site:
S465
Identified Species:
25.33
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S465
R
E
T
K
E
V
D
S
K
E
N
F
S
Y
L
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S465
R
E
T
K
E
V
D
S
K
E
N
F
S
Y
L
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S465
R
E
T
K
E
V
D
S
K
E
N
F
S
Y
L
Dog
Lupus familis
XP_540240
893
101055
E550
I
Q
Q
R
D
T
K
E
L
D
V
K
E
H
A
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
R461
P
F
E
L
I
Q
Q
R
K
T
N
D
L
A
V
Rat
Rattus norvegicus
NP_001099930
804
89584
T461
E
L
I
Q
Q
R
K
T
N
E
L
A
V
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
S455
S
S
C
T
S
N
T
S
E
L
H
E
T
R
R
Chicken
Gallus gallus
XP_001235234
775
85980
G435
T
G
R
K
G
A
H
G
K
V
P
L
S
R
T
Frog
Xenopus laevis
NP_001084841
660
74123
I320
D
N
N
I
D
D
N
I
P
S
E
N
E
K
T
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
A230
P
I
C
V
H
C
S
A
G
C
G
R
T
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
I484
G
A
H
A
K
P
H
I
A
G
K
P
K
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
100
0
N.A.
13.3
6.6
N.A.
6.6
20
0
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
33.3
N.A.
20
26.6
N.A.
26.6
20
13.3
13.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
0
10
0
10
10
0
0
10
0
10
19
% A
% Cys:
0
0
19
0
0
10
0
0
0
10
0
0
0
0
0
% C
% Asp:
10
0
0
0
19
10
28
0
0
10
0
10
0
0
10
% D
% Glu:
10
28
10
0
28
0
0
10
10
37
10
10
19
10
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
28
0
0
0
% F
% Gly:
10
10
0
0
10
0
0
10
10
10
10
0
0
10
0
% G
% His:
0
0
10
0
10
0
19
0
0
0
10
0
0
10
0
% H
% Ile:
10
10
10
10
10
0
0
19
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
37
10
0
19
0
46
0
10
10
10
10
10
% K
% Leu:
0
10
0
10
0
0
0
0
10
10
10
10
10
0
28
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
0
0
10
10
0
10
0
37
10
0
0
0
% N
% Pro:
19
0
0
0
0
10
0
0
10
0
10
10
0
0
0
% P
% Gln:
0
10
10
10
10
10
10
0
0
0
0
0
0
0
0
% Q
% Arg:
28
0
10
10
0
10
0
10
0
0
0
10
0
19
10
% R
% Ser:
10
10
0
0
10
0
10
37
0
10
0
0
37
0
0
% S
% Thr:
10
0
28
10
0
10
10
10
0
10
0
0
19
10
19
% T
% Val:
0
0
0
10
0
28
0
0
0
10
10
0
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _